Biochemistry 40(35):1062510633 Jarquin Campos A, Risch L, Nydegger U, Wiesner J, Vazquez Van Dyck M, Renz H, Stanga Z, Risch M (2020) Diagnostic accuracy of holotranscobalamin, vitamin B12, methylmalonic acid, and homocysteine in detecting B12 deficiency in a large, mixed patient population
J., Von zur Mhlen, A
In line with evidence from GLP-1RA studies, tirzepatide exhibited a stabilizing effect on UACR, leading to a least square mean difference of 31.9 (95% CI 37.7 to 25.7) mg/g with insulin glargine [49]
Tirzepatide (Advanced Program), from $233/mo just $7.70/day SURMOUNT-1 studied the FDA-approved brand tirzepatide product at 15 mg in a defined population and reported a 20.9% average at 72 weeks
What they do not realize is that at week two, they have only reached about 50-60% of their eventual steady state concentration at that dose
Hence, it seems premature, based on the available evidence, to conclude that GLP-1RAs are uniformly capable of inducing atherosclerosis regression