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Similarly, the combined indirect effect from change in HbA 1c and BW was calculated using each mediator as an endpoint in separate MMRMs (as described above), including all mediators and log-transformed hsCRP as baseline values and other relevant baseline variables (confounders) as presented in VanderWeelle 2014 [26], and from these models the proportion mediated was estimated

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Cagrilintide is the most evidence-anchored option because CagriSema shows that adding amylin to a GLP-1 backbone improves outcomes