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Part XI: Technology Roadmap Next-Generation Molecules and the New Exclusivity Frontier New Modalities, New IP Architectures The pharmaceutical industrys shift toward novel therapeutic modalities, including mRNA therapeutics, siRNA/antisense oligonucleotides, cell and gene therapies, and antibody-drug conjugates (ADCs), is not merely a scientific development

The age of onset of the renal disease varied from 2 months to 6.4 years but was most common in infancy and early childhood

However, individual results can vary widely