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IGF-1R activation after ligand binding activates AKT kinases/pathway linked to prevention of apoptosis and the ERK pathway associated with growth and proliferation

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Increased energy expenditure must complement reduced food intake in order to maintain weight loss since physiological compensatory adaptations protect against major weight decrement: decreased caloric intake leads to increased hunger, lower sensitivity to satiety factors, and a reduced metabolic rate [83, 84]

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JiangXShuHJKrishnanKQianMTaylorAACoveyDFet al

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