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More serious but rare side effects can involve changes in blood sugar, mood swings, or hormonal imbalances

doi: 10.3389/fcimb.2024.1380998 38 HuangZ.RoseA

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A 45-degree angle reduces effective penetration depth and is recommended when you can only grasp about 1 inch of tissue, when using longer needles, or when injecting in sites with thinner subcutaneous fat