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In people 60+ years, where muscle loss is biologically inevitable, pharmacological weight loss remains a concern, as even modest lean mass reductions can accelerate frailty

It is currently in phase 3 clinical trials (the TRIUMPH program) evaluating its safety and efficacy for chronic weight management

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Expert clinical insights Drug-naive T2DM with low cardiovascular risk (normal body mass index) The concept of Normal Weight Obesity, often referred to as the thin-fat Indian phenotype, describes individuals with a lower lean body mass but higher subcutaneous fat despite having a normal body weight

These could indicate a serious allergic reaction, and immediate medical attention is required