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Though the recommended doses are not expected to cause adverse effects for the infant, there are no human studies available to assess the risks

According to treatment guidelines, when DMARDs fail, biological agents are recommended (71)

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Daily citrulline feeding was initiated with males 1 week before co-caging, and males were pre-caged with females 1 day before co-caging to prevent mating

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When a full course produces nothing noticeable, additional courses may or may not change the outcome there's no data to guide that decision