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The accumulation of metabolic waste products and alterations in pH can further contribute to a hostile TME, which can impair immune function and promote tumor progression

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10.1152/physrev.00040.2003 166 XiaoY.YangX.LiuK.JiaoX.LinX.WangY.et al (2018)

Pathophysiological conditions such as inflammation and ageing [36] drive the cytosolic GSH/GSSG-coupled redox potential to be more positive (oxidising)