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In the study, 115 patients were randomized to either the Allurion Programa weight-loss platform that combines the Allurion procedure-less gastric balloon for weight loss, the Allurion Virtual Care Suite, and the Allurion Connected Scalewith or without oral GLP-1 agonist semaglutide and followed for four months

In OASIS-4, the top oral dose produced ~13% body weight loss over 64 weeks

The SEMALEAN study, published in 2025, tracked 115 semaglutide patients over 12 months using DEXA scans and found that while total lean mass initially declined, it stabilized by month 12 while fat mass continued dropping throughout

But he is gaunt and now feels he has lost too much weight

Shan et al., 2013)

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