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References Vitamin B12 Product Label Cyanocobalamin injection [package insert]

Evidence Boundary Not supported by published human clinical trial data for dosing, absorption, or efficacy

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Concentration honesty: Clinical studies used 0.01 to 1% topical

Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jul;154:161-171. doi: 10.1016/j.bcp.2018.05.003. Epub 2018 May 5. PMID: 29738706; PMCID: PMC6015571

Goal is to feel the benefit for a solid week, and often longer after adhering to the recommended initial series