why is my semaglutide injection red bump/mark at site? : r/Semaglutide If Ozempic Is in Short

Research indicates that GLP-1 users experience modest reductions in total body water during weight loss phases

Strumila R et al, Eur Neuropsychopharmacol 2024;87:2934)

Diabetic neuropathies: unanswered questions

75 SunZ.LiangM.ChenJ

Variants in GLP1R (the GLP-1 receptor), GIPR (the GIP receptor relevant specifically to tirzepatide's dual-agonist mechanism), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide

Ordinarily this type of darkening happens fairly evenly across the skin and moles/freckles concurrently