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Secondary outcomes included patients developing cerebral infarction, MI, DVT, PE, arterial thrombosis which was defined as the combination of cerebral infarction and MI, venous thrombosis which was defined as the combination of DVT and PE, and all-cause mortality

Because of these findings, doctors may be cautious about prescribing Semaglutide to pregnant women or those planning to become pregnant until more human-based research is available

The primary endpoint of the study is the relative change in body weight from baseline to week 68

Based on the findings, the researchers concluded that initiating GLP-1 therapy was associated with a modestly increased risk of fragility fractures in older adults with type 2 diabetes. They indicated the results may help physicians weigh potential skeletal risks against the drugs expected health benefits

Journal of Investigative Dermatology 117(6):1350-1356. [doi.org]

Chatting through this will usually narrow the options down to one