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Thus, direct GLP-1R signaling in SPNs might have clinical relevance as it may account for increased heart rate, a common side effect of GLP-1R agonist medications 21

Furthermore, MK-677 demonstrates potential benefits in improving bone density and enhancing sleep quality, appealing to individuals seeking to optimize their physical performance

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Suppression of normally occurring reactive astrogliosis worsens neurological outcome and inhibits postlesional plasticity, regeneration and repair, as well as a restoration of the blood-brain barrier, which all determine functional tissue remodelling and post-traumatic rehabilitation

Carla Isabel Marques, University of Coimbra, Portugal