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But in 2021, it was approved as a weight loss aid under the name Wegovy

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26 To determine whether TGF 1 is exerting its effects through a SMAD3-dependent mechanism, bEnd.3 cells were treated with rTGF 1 and the SMAD3 antagonist SIS3

Zepbound, as expected, was more effective in promoting weight loss

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If the blockage causes a perforation or tear of the intestine, bowel contents could leak out into other parts of the body, putting the patient at risk of life-threatening infections like peritonitis and sepsis