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The CBS upregulation hypothesis and thats all it was has been discredited for at least 8-10 years

Skin and collagen remodeling research driven mainly by GHK-Cu, with topical clinical evidence for collagen synthesis and skin density

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Singh V, Gamage H, Jones A, Wood HV, Bruning B, James A, Van Drie P, Purushotham N, Oppenheimer R, Dalal RC