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The lactate shuttle hypothesis further revealed its pivotal roles in oxidative substrate transport and cellular signaling via monocarboxylate transporters (MCTs), leading to its recognition as a potent signaling metabolite, particularly through its receptor GPR81 (6-8)

Muhimbili University

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67 A Bayesian network meta-analysis pooled data from 54 RCTs involving 49 602 participants, of whom 28 353 received GLP-1 RA treatment demonstrated that GLP-1 RAs were associated with a reduced risk of fractures compared to placebo or other antihyperglycemic agents

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