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Those effect sizes are big enough that, when even a modest share of adults use them, you can start to see movement in the population data

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Despite most children with CVS may experience bilious emesis and severe abdominal pain, they might also underline the presence of serious surgical and non-surgical disorders

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If 11% discontinued due to AE, surely a greater number had a rough ride on therapy and this cohort at a minimum require an alternate approach / therapy