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About this article Cite this article van der Walt, A., Strijbis, E.M.M., Bridge, F

Male patients predominantly experienced AEs within the initial 30-day window following treatment initiation, whereas female patients exhibited a delayed onset pattern, with the majority of AEs emerging after 360 days of continuous therapy

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It might be helpful to visualize that concave up intervals could hold water, while concave down intervals could not hold water

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10.1016/j.biopha.2016.11.098 98 MitraK.GautamS.KondaiahP.ChakravartyA