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It is why patients with a personal or family history of medullary thyroid carcinoma, or Multiple Endocrine Neoplasia syndrome type 2, are excluded from GLP-1 treatment

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Nevertheless, preliminary findings suggest that it can maintain weight loss for up to 5 years, given adherence to dietary and lifestyle changes

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This research theorized that hyperglycemia can lead to a downregulation of GIPr causing decreased GIP response despite therapeutic or even supratherapeutic levels of GIP [21]