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Non-opioid neurotransmitter systems that contribute to the opioid withdrawal syndrome: a review of preclinical and human evidence

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Its clearance can increase due to the saturation of its transport system, particularly at high doses or with chronic supplementation because of the reported skeletal muscle store saturation [23]

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Its sequence Aib-His-D-2Nal-D-Phe-Lys-NH incorporates an -aminoisobutyric acid (Aib) N-terminal residue, D-configuration amino acids at positions 3 and 4, and a C-terminal amide, all of which contribute to protease resistance and receptor selectivity