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Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses

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However, it is important to emphasize that, at present, robust clinical evidence for dual and triple agonists is derived predominantly from adult populations

Step Four If your journey continues past 12 weeks, 30-minute check-ins monthly as needed until we reach your goal