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Phase I biotransformation seems to be enzymes that catalyzes oxidation, reduction or hydrolyze reactions, it usually converts substrates to more polar forms by introducing or unmasking a functional group (e.g., OH, NH2, or SH)

Or if the vial in my hand is part of the batch that was tested - especially because the document is now six-months-old

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Caspase activation is one of the major mediators of the apoptotic response