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That was 14 people who lost an extreme amount of weight extremely fast on television, which is not most people's situation

For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results

Some newer drugs combine GLP-1 receptor agonists with other metabolic targets or additional mechanisms to achieve more effective weight loss

Fortunatley, telehealth companies exist to make GLP-1 meds more accessible and affordable, while also offering monthly support from qualified medical experts

Eating discipline matters during the transition gap to avoid regain that erases tirzepatide progress

Someone else losing faster does not mean your medication works less effectively