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When applied to the skin, it may also cause mild skin or eye irritation ( Additionally, there is concern over mixing MSM with alcohol since other sulfur-containing medications can cause adverse reactions when mixed with alcoholic beverages ( However, no studies have explored this potentially problematic combination yet

A defective pentose phosphate pathway reduces inflammatory macrophage responses during hypercholesterolemia

Folate: A deficiency in folate has been linked to peripheral neuropathy