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How Berberine triggers GLP-1: Studies suggest that berberine helps stimulate the secretion of GLP-1, aiding in better appetite control and glucose metabolism

doi: 10.1001/jama.2023.19574

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Borrowed from munitions manufacturing, it boosted metabolism by forcing the body to waste energy as heat

33.4 pM for GIP) but approximately 13-fold weaker potency than GLP-1 in activating GLP-1R (EC50 = 934 pM for tirzepatide vs.70.5 pM for GLP-1)

Lancet Neurol 19(7):582590 Onaolapo AY, Ojo FO, Adeleye OO, Falade J, Onaolapo OJ (2023) Diabetes mellitus and energy dysmetabolism in Alzheimers disease: understanding the relationships and potential therapeutic targets