Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023
Back Rehfeld, JF (2018) 'The origin and understanding of the incretin concept', Frontiers in Endocrinology' , 9, 387
This means it acts on three hormone receptor pathways involved in appetite, fullness, blood sugar control and energy balance
If youre trying to lose weight, exercise compliments GLP-1s by helping us burn calories, reduce fat mass and preserve lean muscle mass, which helps us burn more calories
Store it in a refrigerator between 36F46F (2C8C) to help prevent side effects such as vomiting
Refrigerate 28 C