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Clinical evidence The effectiveness of combination therapy with PIO (1530 mg daily) and tofogliflozin (TOFO 20 mg daily) for 24 weeks was investigated in 32 patients who experienced T2D and NAFLD in an open-label RCT [116]

Another antioxidant enzyme whose level is a good biomarker of oxidative stress is Peroxiredoxin (PRX)

While a decrease in serum urea level and an increase in serum creatinine level were detected in the MTX group, WPC administration reversed these results up to control group levels

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In parallel, emerging data from male reproductive studies suggest that GLP-1RAs may positively influence the hypothalamic-pituitarytesticular axis, improve testicular function, and enhance spermatogenesis, particularly in obese men