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doi: 10.1016/j.shaw.2013.07.004 125 YeMBeachJMartinJSenthilselvanA

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Your pituitary gland releases GH in pulsatile bursts throughout the day, with the largest pulse occurring 90120 minutes after deep sleep onset

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A number of clinical observations suggest that Down patients may have a functional folate deficiency despite having normal plasma levels of folate and vitamin B 12 [13]