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doi: 10.1126/science.abj8754 17 BarS.WilsonK

The phase 3 TRIUMPH-4 data showed these rates at 9 mg and 12 mg doses respectively: Nausea: 38.1% and 43.2% (vs 10.7% placebo) Diarrhea: 34.7% and 33.1% (vs 13.4% placebo) Constipation: 21.8% and 25.0% (vs 8.7% placebo) Vomiting: 20.4% and 20.9% (vs placebo) These numbers are higher than cagrilintide monotherapy across the board

This is in keeping with a previous pharmacodynamic study that found lixisenatide 20 g OD and BD significantly improved HbA 1c to a similar extent compared with placebo over a 4-week treatment period [8]