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A clinician may consider combination therapy when metformin alone does not meet individualized glucose goals, when weight is a major treatment factor, or when a GLP-1 receptor agonist fits the broader cardiometabolic plan

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For women who are using birth control pills, doctors should think about whether another method would be a better fitespecially if the new drug could affect how hormones are absorbed

The MHRA authorised a Wegovy semaglutide tablet for weight management in June 2026

Find out in our article about supplements that may help or worsen acid reflux

Consider VSL#3 if you have a history of GI issues predating semaglutide, if standard probiotics have not resolved your symptoms after four to six weeks, or if your provider recommends a high-potency formulation