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In addition, zUPREME-1 Phase 2 topline results presentation

The reason that its gaining so much interest is due to its apparent ability to promote healing across multiple tissue types, from muscles and tendons to bones and even nerves

The initial conversion occurs in the liver, where 25-hydroxylase enzymes produce 25-hydroxyvitamin D [25(OH)D], the major circulating form and standard biomarker for vitamin D status

L.BottaryR.SchoerningL.BaerL.GonencA.Eric JensenJ.et al (2020)

This more aggressive approach requires careful monitoring and may suit men who tolerated the initial doses without difficulty