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8 Fiber Soluble fibers like inulin, beta-glucans, and resistant starch nourish gut bacteria, leading to increased butyrate, which increases GLP-1 production
Gastrointestinal effects Nausea dominates the side effect landscape
Other reported effects included: Transient fatigue Reduced appetite (therapeutically desirable in the context of weight loss) Mild injection-site reactions Altered skin sensations or cutaneous hyperesthesia (reported in ~7% of participants, mild and non-serious) Serious adverse events were rare and occurred at similar rates in the retatrutide and placebo groups (approximately 4%)
Preparing injectables outside a USP 797-compliant facility introduces contamination risk patients cannot see, including bacterial, fungal, and particulate contamination that can cause injection-site infections, systemic infections, and in severe cases sepsis
Some reviews flag dosing errors and auto-renewal surprises