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J Neurol Neurosurg , 2015, 2(1): 009

Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning

Researchers should also recognize that the combinations per-unit efficiency means that a well-designed combination protocol frequently achieves a larger research signal at a lower total compound cost than a single-compound protocol producing the same effect, which is part of why the combination dosing approach dominates the published GH-axis research literature

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I do have bipolar disorder and on medication but my depression is a lot worse now