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As inflammation begins to resolve, concentrations of cytokines such as TNF- and IL-1 progressively decline, whereas levels of anti-inflammatory and pro-repair mediators including TGF- and IL-10 increase (116) scRNA-seq reveals that core transcription factors such as NF-B1 and STAT6, as well as non-coding RNAs including miR-155 and the lncRNA MALAT1, regulate the polarization process