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The phase 3 titration schedule follows the same principle of 4-week escalation steps but with slightly adjusted intermediate doses

doi: 10.1007/s00441-019-03049-z 7 LeeCZengJDrewBGSallamTMartin-MontalvoAWanJet al

The imbalance between capacity and demand has narrowed but not disappeared

Many patients find that after four to six weeks at a stable dose, diarrhea either resolves completely or becomes minimal and manageable

In a 3D layer-by-layer assembly process, after each compartment of the PDR-MNs was prepared, the patch was assembled as described in our previously reported work [4143]

7.1 Critical long-term safety evaluation Numerous critical safety factors need consideration in the selection of patients