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Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis and an oncogenic c-MYC transcriptional target (Bello-Fernandez et al., 1993), decarboxylates ornithine to form putrescine, the first mammalian polyamine

These data enhance the notion that even if, in theory, either peak relative to the GS-NEM conjugate can be used for calculations, the peak eluting at about 4.29 min r.t

Treatment with IGF-1 rescues cell apoptosis The effect of hyposialylation on IGF-1R function was further assessed by understanding cell cycle progression of GNE knockdown and mutant cells

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

During the HMs-induced ROS scavenging system the GSH is changed to its oxidized form (GSSG) which is one of the key processes of the redox signaling process (Figure 3)

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