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Oral B12 supplementation generally takes longer to produce noticeable effects than intramuscular injections, with patients typically experiencing improvements within 24 weeks

There are two forms of B12 used in injections: methylcobalamin and cyanocobalamin

Because the intranasal forms have lower absorption than the IM dosage form, intranasal B12 forms are administered once weekly

Retrieved 17 January 2017

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The boost in energy happens because the vitamin B12 is absorbed directly into your bloodstream through the shot