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Frequent vomiting can dehydrate you, especially during the adjustment period when youre still getting used to the medications effects

But some researchers titrate too slowly, sitting at sub-therapeutic doses for months

The before and after photos for this BMI range are often the most visually striking because the weight loss is large enough to be obvious but the starting point is not so high that significant loose skin becomes a major factor

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Lastly, most trials (and observational studies) did not consider duration of diabetes as an eligibility criterion or account for this by subgroup analyses

A 2025 randomised crossover trial published in Nature Medicine (Pasqua et al.) tested weekly semaglutide alongside automated insulin delivery in adults with T1D