While selectivity over classical ERs is reported at relevant concentrations, nuclear-receptor cross-reactivity and downstream network effects remain theoretical risks in longer or higher-exposure studies
Back to Journals Drug Design, Development and Therapy Volume 19 Semaglutide Therapy and Accelerated Sarcopenia in Older Adults with Type 2 Diabetes: A 24-Month Retrospective Cohort Study Received 1 April 2025 Accepted for publication 25 June 2025 Published 3 July 2025 Volume 2025:19 Pages 56455652 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Tuo Deng Qingjuan Ren, Lei Zhi, Hongfang Liu Department of Geriatrics, Shijiazhuang Peoples Hospital, Shijiazhuang, Hebei, Peoples Republic of China Correspondence: Qingjuan Ren, Department of Geriatrics, Shijiazhuang Peoples Hospital, Shijiazhuang, Hebei, Peoples Republic of China, Email [email protected] Purpose: This study aimed to investigate changes in muscle mass and strength among older adults with type 2 diabetes who were treated with Semaglutide
This makes it different from semaglutide, which only targets the GLP-1 receptor
Appetite 48 , 338344 (2007)
Keep in mind that the liver and kidneys may be impacted by a high glutathione intake
Maintain 6 mg for at least 8-12 weeks to assess response before considering further escalation
