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Humoral immunity involves autoreactive B cells and plasma cells that produce high-affinity antibodies against Tg and TPO, furthering tissue injury through complement activation and antibody-dependent cell-mediated cytotoxicity (ADCC)

Compared to Neuromax B12, Sucrosomial B12 resulted in significantly higher circulatory vitamin B12 levels at every post-treatment timepoint ( p 0.023)

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Together, the findings suggest that the development and use of advanced in vitro kidney models are important improvements in renal drug safety assessment

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