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Core needle biopsy or incisional biopsy is required for definitive diagnosis

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Cellular senescence was assessed by SA--galactosidase staining (SA--gal staining) using senescence -galactosidase Staining Kit (Cell Signaling Technology, Beverly, MA, United States) according to the manufacturers instructions

TET hydroxylase activity decreased along with Tet1 gene expression

ROS holds an oxygen atom with an unpaired electron in its outer shell