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doi:10.1016/j.cub.2017.09.019

4 Primary Dermal Melanoma Primary dermal melanoma (PDM) is a very rare subtype of melanoma (0.8% of all MMs [2, 23]), exclusively confined to the dermis

Quick Answer: Tirzepatide likely has minimal direct blood-brain barrier penetration due to its large molecular size (approximately 4,800 daltons), but produces central nervous system effects through indirect pathways

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