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These include severe dysmenorrhea requiring prescription analgesics, progressive worsening of menstrual pain, pain occurring outside of menstruation, deep dyspareunia, and cyclic gastrointestinal or urinary symptoms (Kennedy et al., 2005)

Who is most at risk

These symptoms often build up slowly, making them easy to overlook

Examples include: Antimetabolites: Drugs like methotrexate, which block DNA synthesis, can be lessened by high B12 levels