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doi: 10.3389/fimmu.2022.804597 Received 29 October 2021 Accepted 07 March 2022 Published 30 March 2022 Volume 13 - 2022 Edited by Fabio Malavasi, University of Turin, Italy Reviewed by Arabella Young, University of California, San Francisco, United States

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Systemic inhibition of ferroptosis raises legitimate concerns about potential side effects, particularly the suppression of anti-tumor immunity, given the role of ferroptosis in immune surveillance