They are costly
Evidence now shows that consistent weight loss occurs when GLP-1 therapy continues, with weight regain beginning 3 to 6 months after discontinuationunderscoring the importance of ongoing treatment strategies
Additionally, paeoniflorin was reported to reduce the expression of the L-tryptophan-catabolizing enzyme tryptophan-2,3-dioxygenase in the liver of stress-induced depressive mice, thereby increasing the 5-hydroxytryptamine/tryptophan ratio and decreasing the kynurenine/tryptophan ratio (Liang et al., 2023)
Macular and papular areas (fried egg appearance) may be present within a single lesion
Dosing protocols Phase 2 clinical trials used a titration schedule starting at 0.5mg weekly, escalating through 1mg, 2mg, 4mg, 8mg, and reaching maintenance doses of up to 12mg weekly over several months
Same medication, same injection guidance