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Glinide compounds like repaglinidewhich also act by closing the ATP-dependent potassium channelsappear to be associated with a similar risk of adverse cardiovascular sequelae than sulfonylureas [13]

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The substantial weight loss these medications produce can include loss of lean muscle mass alongside fat, which has implications for long-term metabolic health and physical function

Semaglutide reduces A1C by approximately 1.5% to 1.8% while producing significant weight loss