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Recent articles show that SARS-CoV-2 infection can complicate the onset of several autoimmune and autoinflammatory diseases, including MIS-C and Guillain-Barr syndrome, that need fundamental immunological therapies, such as immunoglobulin ( MIC-S is an inflammatory disease arising after exposure to SARS-CoV-2, may progress to systemic and vascular changes, and is potentially lethal