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Habener, Jens Juul Holst The pleiotropic local and systemic actions of GLP-1 and GLP-2 secreted in response to nutrients, bacterial metabolites, or inflammatory toxins and cytokines, from enteroendocrine L cells of the small and large intestine.

10.1016/j.jogoh.2020.101698 65 NouriK.WalchK.WeghoferA.ImhofM.EgarterC.OttJ

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The results showed that 15 g ID glutamine significantly enhanced GLP-1 and glucagon concentrations with modest increments in insulin levels and phasic pyloric pressures in both groups [36]

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Nicotinamide supplementation attenuates renal interstitial fibrosis via boosting the activity of sirtuins