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FOXO4-DRI (Proxofim) FOXO4-DRI (Proxofim) is a synthetic peptide studied for its ability to target senescent cells by disrupting FOXO4p53 interactions

The reduced intracellular NAD + concentration limits the deacetylase activity of SIRT1, resulting in elevated H4K16Ac and gene expression

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Shiheido, Y

Further research revealed that silencing CBS hinders Sp1 nuclear translocation, thereby affecting Sp1 binding to the SREBP-1a promoter site

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