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According to this model, D-2 stimulants correct the hypodopaminergia, lowering the overnutrition reward (100102)

Semaglutide works by mimicking the action of endogenous GLP-1 , enhancing glucose-dependent insulin secretion, suppressing glucagon release, and slowing gastric emptying

Semaglutide GLP-1 injections for weight loss are not recommended for use on patients who also have been diagnosed with type 1 diabetes, decreased kidney function or kidney disease, medullary thyroid cancer, or disease of the gallbladder

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The glucagon component adds its own gastrointestinal effects on top of the GLP-1 and GIP effects